Thursday, November 15, 2007
Do we really want to know what all is hiding in our genes?
What medicine is the best, do you carry inside of you marks of Dingiskan or you are perfect candidate for depression or alzenheimer,s disease. Science is armed with unraveled sequence of human genome, and is digging dipper in our biology, at the same time is dropping more and more genetic tests, which from our DNA reading mysteriously messages from our past, present and future.
Our genom is script , that is saved on molecule DNA , which is coiled in 23 pairs of chromosomes, and is leading in core of our cells. Not long ago was this script terra incognita: on the maps of scientists there was big black mark, in which was here and there small part of light of already looked into areas.
Everything turned upside down in year 2001, when scientist presented to world, that they read complete human genome, they defined sequence of nearly three hundred milliards chemical letters, which make our encyclopedic of life. The action is similar as reading some very dick book, whit that exception that book is written with only four chemical letters
A, C, G and T.
Discovery of human genome opened the doors to new brand of science- genomics., and it seems that it will finally discovered the deepest questions in our biology, like: what is genetic ground of our superiority related to other beings living on earth, and the mystery of our beginning of existence. Along this they are working on our in between differences which is consequence genetic factors , and also our acceptance on diseases as cancer to intellectual and physical potentials.
Rummaging of researchers in genome gave many surprising findings. In usa, great britain, are in last few years forming companies , which are giving service in many varieties of genetic tests, from ones that discover is coffee harmful for you to tests that discovers if you are descendant of some famous person like Dgingiskan.
Chaos And Dark Matter
Six years ago when scientist had for the first time in front of them uncovered human genome map, they were astonished over the look of it.Most sophisticated plan of biology is not even a little comparable to map that we can imagine. All together looks like a big mes without a leading thread or shape. So that this is platform for beginning of human creature, which is able to think, seemed unbelievable. Bizarre, but in our genome there is plenty of parasites and dead bodies, it has more similarities with hundred years old tree, full of dead ropes than healthy source of life.
In some points of view it looks like yours garage, it is very individual, but not tide up: there is little evidence on organization; there is so much old crowd; practically nothing is not thrown away; and there is a bit of things with great value messed around without any organization.
Half a century ago, in beginnings of molecular biology, the experts imagined that genome is only a simple and nicely organized book of genes
where in style to gene A follows gene B, and then gene C and so on, like in some kind of cook book the recipes. After all the genes were unbeatable primadonas of genetics. Genes are those demands from general base, which command the cells what to do. People we are results of our genes, so our genome is nothing else than catalog of all our genes that is the way that went the public logics.
But it failed apart together with glamorous status of genes, when we realized and it became public, that that genes occupied as little as one percent of genome. It is like the Encyclopedia Britannica would have on thousands of pages only ten pages with explanation of facts, and those ten pages would be lost incaotic relationship with the whole book, hiden in the sea of unuseful data. Can you imagine? that is the way our genome is organized.
And if there is only percent of gene, why we need 99% of script around in our genome? At first the investigators thought that all that data is not usefully, that most of it it is simply waste and crowd, that got collected through millions of years of evolution and so just stayed there, because there was no one to erase it. It seems really heretic, that the nature would neglect and behave uneconomic. In all that disappointment that part of genome got calling JUNK DNA.
Lion part of that not useful crowd are presented as sequence with not much of a kind name PARASITE DNA. It is also known as jumping gene or Selfish DNA, which got that name because of a habit , that is jumping around over genome and and are leaving their marks as it falls. It can also happen that it falls in some gene and then it destroys. How carefully it is accomplishing its mission are showing facts that the prime champions of parasites are elements L1 and Alu, in human both of them loaded in around million copies and together they occupies third of space in genome.
In genome we can also found creatures as are Zombie gene or so called pseudogene. These are dead genes, that like some kind of ghosts scary around our genome and somehow meanwhile some of them awake from their grave. Pseudogenes were million years ago normal genes, that got the death shoot- they were buried by mutation. Our genome is mass grave yard, because in there lays at least twenty thousand pseudogene corps, which is enormous number, if we think that this amount is not much less than amount of our normal genes.(I found some nice explanation of them in someones blog:"The zombie gene, when attached to human DNA mutates it so that only the most primitive of impulses are received. This has to do with synapses along the central nervous system. Due to the fact that zombies are now dead and subject to decay, these synapses also degenerate so they are no longer receptive to more sophisticated or refined impulses.") And also between those normal genes we can found some that are out of space. So who is the god then, what is so gorgeous about it... Guys I'm amazed by those facts and i will write more about it soon.